Post-translational regulation of KCC2 in the rat hippocampus
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چکیده
To my mother, Ammi. "Cling to her feet, because paradise is there" (Prophet Muhammad).
منابع مشابه
Functional expression and subcellular localization of the Cl- cotransporters KCC2 and NKCC1 in rodent hippocampal and neocortical neurons
1. Review of the literature......................................................................................... 1 1.1. Studying the functional activity of ion transporters .......................................... 1 1.1.1. Comparison of ion channels and ion transporters........................................ 1 1.1.2. Electroneutrality of cation-chloride co-transporters and its impact on ...
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Functional expression of the K-Cl cotransporter KCC2 in developing central neurons is crucial for the maturation of Cl(-)-dependent, GABA(A) receptor-mediated inhibitory responses. In pyramidal neurons of the rodent hippocampus, GABAergic postsynaptic responses are typically depolarizing and often excitatory during the first postnatal week. Here, we show that a single neonatal seizure episode i...
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A robust increase in the functional expression of the neuronal K-Cl cotransporter KCC2 during CNS development is necessary for the emergence of hyperpolarizing ionotropic GABAergic transmission. BDNF-TrkB signaling has been implicated in the developmental up-regulation of KCC2 and, in mature animals, in fast activity-dependent down-regulation of KCC2 function following seizures and trauma. In c...
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Introduction: Calcium/calmodulin-dependent protein kinase II (CaMKII) is highly expressed in the hippocampus, which has a pivotal role in reward-related memories and morphine dependence. Methods: In the present study, morphine tolerance was induced in male Wistar rats by 7 days repeated morphine injections once daily, and then gene expression profile of α-isoform of CaMKII (CaMKIIα) in the hipp...
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The K-Cl co-transporter KCC2 plays multiple roles in the physiology of central neurons and alterations of its function and/or expression are associated with several neurological conditions. By regulating intraneuronal chloride homeostasis, KCC2 strongly influences the efficacy and polarity of the chloride-permeable γ-aminobutyric acid (GABA) type A and glycine receptor (GlyR) mediated synaptic ...
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